Season of all Continents

Origins from many become one,

Bua pan or water lily

from Asia on my balcony

See Europe’s Sage “Azury snow”.

Mammillaria schiedeana,

Mexican, give flowers like meadow

Thai season has got lots to show

The World knows our summer suits for all.

-Wi Tanramluk

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MWIT: Bioinformatics & Drug Design

Interactive Slides

Handout (PDF)

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ขอความกรุณานักเรียนใช้ชื่ออีเมลของ MWIT (ส่วนที่มาก่อน@mwit.ac.th) เป็น username ในการเล่น Quizizz เพื่อให้อาจารย์ตรวจข้อสอบได้ค่ะ
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Full Bloom

วันที่ดอกไม้บาน
The day flowers are in full bloom;
People disappeared from street.
Shoppers by the side road are doomed;
Customers are in panic.

When will peace restore &
Trust from public re-arises?
They don’t step out of the door.
Pandemic is rolling the dices.

Progress

Early in the day, sky is dull

Just like our courage when beginning.

With progress through the day, it’s shining

Nicest thing happens when the time is ripe.

 

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Photos taken by Wi on 31/5/2018 at Petchburi, Thailand

Bored at Work

The road is full of flowers.
Nature awarded you with these prize
Walking to see butterflies…
Free my mind from a tight cubicle
Of dim light & room full of papers,
Computer-generated pollutant,
Block my mind, blur my sight, freeze my hand.
Let’s make plan, see flowers, worth the time.

Non-perfectionism

Once I asked my sis what is best
When my hair is straight or updo
My sis say it is all up to you
Woman do have several styles.

Nothing is the best of all things
We can bring our looks to all types
Today, tomorrow, all those kinds
just what you feel like, do them all.

#philosophyofhairdo #non-perfectionism

Analogy of Drug Target in cartoon

My analogy of cat’s face with drug target such as HIV-protease. What makes them look like a cat? Conserved features (ears and whiskers), and Differential features (eyes and the shape of the face)

Screenshot (4)

Drug is an inhibitor that stop the cat from meowing, such as this Star Corps Trooper helmet.

Screenshot (5)

Let’s see what are possibilities if we are to fit cat’s face with a Star Corps Clone Trooper Helmet

Screenshot (6)

 

Screenshot (7)

Bad target arises when Tom’s picture is in complex because Jerry is there and it is of low resolution

Screenshot (8)

Fluff friend cat called Syri and Garfield looks so common. The colour are the same and they have no special features, and they are promiscuous. If we have enough amount of pictures and they are in the same pose without distortion, it help with the design.

Screenshot (9)

To discriminate them for helmet design, we need to understand their special features. If they are too similar, we may misidentify closely related cats such as the two kitties from Sanrio. It shows the reason why something we are targeting can fit the same models (this may cause drug’s side effects in the case of kinases)

Screenshot (10)

Felix and Sylvester are unique. They are easy for the design of specific helmets for masking them.Screenshot (11)Most of the effort is CRISPR-cas9 is devoted to find a smart synthetic cat or a helmet that can perform our goal to control these mask singers.

 

 

 

Scientist Quest Poetry

At night on recliner chair,
Somewhere in quiet corner,
I was thinking and wonder
What is the purpose of life?
It is neither a trip to see God,
Nor a praise on award and prize.
It is the peace of mind
When life is on struggle.
Destination is just one end.
Life happened to be a hassle
Along roads and river of the world,
I puddle and sometimes have to climb
Up to the top of the mount,
Heading south and north and up the sky.
Well rounded experience till we die
Should be used to try to answer:
The great mystery of the earth,
The birth of a new discipline,
The revolutionized way of doctrine,
To imagine quarks to the universe,
To link the molecules to diseases,
To release energy of mother earth,
To cure the incurables and to reverse,
The curse from sickness to healthy lives.
-Wi Tanramluk

Why drug design researchers need MANORAA?

  1. We are in the era with 100,000 protein structures available. Now we need to analyse what the crystallographic community already have rather than predicting probes in the vacuum.
  2. When you know the ligand is bound inside the identifiable PDB crystal structure, it is surely affect that protein and we showed you the associated Ki from peer-review literature. So that is how we build the bridge from structures to precision medicine.
  3. The residues that you want to fish out from the multiple alignment conservation may be there but may not be a must. The atoms that must be there are atoms that stay there and pair up with the ligand most of the time. The residues that causes the change in binding affinities is what you want to fish for selectivity.
  4. What the drug community need is perhaps a linker such as MANORAA to go all the way from ligands to proteins, pathways, SNPs and target human organs plus a bit of help from the collaborative effort from various disciplines.
  5. It is the very first attempt that ligand structures can complement the drug discovery pipeline with mostly experimental data source support to the expression levels.
  6. It works on your phone, tablet, mac and PC so I can browse my drug on the go.
  7. Its ligand superposition function allows you to make programmable code for fragments superposition on the URL so your drug fragment remains anonymous.
  8. It is open and free but we will need to survive on citation.

Reference: MANORAA paper

 

 

Newton and I

เมื่อฉันรู้ว่าเป็นศิษย์ของปรมาจารย์ปู่ Sir Isaac Newton

When I know that my academic genealogy can be traced back to Sir Isaac Newton.

 

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17thGenerationsToNewton