Bored at Work

The road is full of flowers.
Nature awarded you with these prize
Walking to see butterflies…
Free my mind from a tight cubicle
Of dim light & room full of papers,
Computer-generated pollutant,
Block my mind, blur my sight, freeze my hand.
Let’s make plan, see flowers, worth the time.

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Winner’s tears

Sighing right by the bridge
My mission was completed
All tasks were well succeeded
People greet me with honours.
But life before now was cruel
I am a fool of my own mirror
Deep down I feel sour
Those hours of emptied life.
Dukka and anatta
Chiva, when I have cried
Till tears dried inside my eyes
But tried to smile to the crowd
Living my life to excess
Stressed my soul in and out
Till the day I was about
Have to leave this body alive
Haunting me until now
When I am about to fight
The tears in the back of my eyes
Remind me of the failure
That fame is empty without me
Those tasks will be taken
Those money will be spend
Those hidden treasure will disappear
When I was no longer me
My parent who I see in tears
My body looked peculiar
My fear reached its new high.
The pain cannot be cured
My pure soul was burnt alive
Though reborn after it died
I can’t uncried those tears.
It’s absorbed into my blood
And flush up when I gear
Towards a new height that I fear
My tear of being buried alive.
-Wi Tanramluk
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Why drug design researchers need MANORAA?

  1. We are in the era with 100,000 protein structures available. Now we need to analyse what the crystallographic community already have rather than predicting probes in the vacuum.
  2. When you know the ligand is bound inside the identifiable PDB crystal structure, it is surely affect that protein and we showed you the associated Ki from peer-review literature. So that is how we build the bridge from structures to precision medicine.
  3. The residues that you want to fish out from the multiple alignment conservation may be there but may not be a must. The atoms that must be there are atoms that stay there and pair up with the ligand most of the time. The residues that causes the change in binding affinities is what you want to fish for selectivity.
  4. What the drug community need is perhaps a linker such as MANORAA to go all the way from ligands to proteins, pathways, SNPs and target human organs plus a bit of help from the collaborative effort from various disciplines.
  5. It is the very first attempt that ligand structures can complement the drug discovery pipeline with mostly experimental data source support to the expression levels.
  6. It works on your phone, tablet, mac and PC so I can browse my drug on the go.
  7. Its ligand superposition function allows you to make programmable code for fragments superposition on the URL so your drug fragment remains anonymous.
  8. It is open and free but we will need to survive on citation.

Reference: MANORAA paper

 

 

Old Book Chemistry

Digging through old books from the shelf,
Discovered thyself memory.
Old books have some chemistry
From primary school back then.

I dreamt to reach the star
Thus far seems out of my fence.
My imaginary abstinence
Has happened from so many things.

Out of my familiar zone,
On a few smart phones and my bench,
Distraction that I have befriended
Suck persistence out from my soul.

Is this called a burn out–
When we’re aroused by nothingness?
Should not that be a bless
To access window of the life,

When fire inside was absent
When we don’t want to fight
When mountain seems so high
&Simple life is my medal.

%Contribution & Reward

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If old times we divided by percent,
Who remain first author, who comes last,
Money and success reached this regard,
Who rewarded nature by which percent.

ถ้าตอนนั้นมัวแต่คิดแบ่งเปอร์เซ็นต์
โลกที่เห็นตอนนี้เป็นเช่นไรหนอ
เงินต้องน้อยงานต้องดีไม่ยอมรอ
เค้าคงท้อหนีหายไปหลายคน

ธรรมชาติมีความลับไม่สิ้นสุด
มาสะดุดที่แบ่งกันเห็นเห็น
ว่าก่อนทำใครได้ทำกี่เปอร์เซ็นต์
แล้วที่เห็นมันคิดเป็นเท่าไหร่กัน

ธรรมชาตินั้นไม่มีลิมิต
มันใช่สิทธิ์ของเรามาแบ่งสรร
ได้มาร้อยนั้นคิดเป็นเท่าไหร่กัน
ก็แค่นั้นเป็นเศษเสี้ยวธุลีทราย

แล้ววาดภาพการไต่กระไดชีพ
ว่าได้หยิบชิ้นปลามาเท่าไหร่
ตอนยังอยู่เทสลาได้เท่าใด
อุดมการณ์เป็นงานขายไม่จีรัง

-Wi Tanramluk