Non-perfectionism

Once I asked my sis what is best
When my hair is straight or updo
My sis say it is all up to you
Woman do have several styles.

Nothing is the best of all things
We can bring our looks to all types
Today, tomorrow, all those kinds
just what you feel like, do them all.

#philosophyofhairdo #non-perfectionism

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Why drug design researchers need MANORAA?

  1. We are in the era with 100,000 protein structures available. Now we need to analyse what the crystallographic community already have rather than predicting probes in the vacuum.
  2. When you know the ligand is bound inside the identifiable PDB crystal structure, it is surely affect that protein and we showed you the associated Ki from peer-review literature. So that is how we build the bridge from structures to precision medicine.
  3. The residues that you want to fish out from the multiple alignment conservation may be there but may not be a must. The atoms that must be there are atoms that stay there and pair up with the ligand most of the time. The residues that causes the change in binding affinities is what you want to fish for selectivity.
  4. What the drug community need is perhaps a linker such as MANORAA to go all the way from ligands to proteins, pathways, SNPs and target human organs plus a bit of help from the collaborative effort from various disciplines.
  5. It is the very first attempt that ligand structures can complement the drug discovery pipeline with mostly experimental data source support to the expression levels.
  6. It works on your phone, tablet, mac and PC so I can browse my drug on the go.
  7. Its ligand superposition function allows you to make programmable code for fragments superposition on the URL so your drug fragment remains anonymous.
  8. It is open and free but we will need to survive on citation.

Reference: MANORAA paper

 

 

Craft

I sprayed the gold colour in my bedroom because it was too windy outside in the winter time. The smell of that colour spray stayed for days so I do not recommend anyone to repeat my courage to do it besides your bed.

Below: Sala Thai and Line Thai stencils I designed for Thai Night 2008 back in Cambridge.

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A protein kinase with correct dimension in all angles. That time there was not a 3D printer yet. So I fold it by hand.

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A scarf for lady mouse I knitted from leftover wool with a couple toothpicks.

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How to Read Wi’s Poem

I have been practicing how to master Thai’s 8-word poems to translate lots of my กลอนสุภาพ collection to English. With this type of poem, you basically pronounce them by fitting the sentence in 3/2/3 or 3/3/3 words and pausing in between as shown below.

Obstacle.... is there! ....."bearable"
 From a girl..... can become..... a lady
 Works my way..... to fullest..... dignity
 With happy.... young soul.... from within.
 -Wi Tanramluk

The advantage of having this type of fixed rhyme is that it is easier to memorise lengthy stories as there was a connection of vowels between each sentence. Since the thai sentences has no full-stop and no tenses, you will find sometimes my sentences are very long but the use of words towards the gist of story are connected both in sound and in meaning.

 

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