Bored at Work

The road is full of flowers.
Nature awarded you with these prize
Walking to see butterflies…
Free my mind from a tight cubicle
Of dim light & room full of papers,
Computer-generated pollutant,
Block my mind, blur my sight, freeze my hand.
Let’s make plan, see flowers, worth the time.

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Non-perfectionism

Once I asked my sis what is best
When my hair is straight or updo
My sis say it is all up to you
Woman do have several styles.

Nothing is the best of all things
We can bring our looks to all types
Today, tomorrow, all those kinds
just what you feel like, do them all.

#philosophyofhairdo #non-perfectionism

Analogy of Drug Target in cartoon

My analogy of cat’s face with drug target such as HIV-protease. What makes them look like a cat? Conserved features (ears and whiskers), and Differential features (eyes and the shape of the face)

Screenshot (4)

Drug is an inhibitor that stop the cat from meowing, such as this Star Corps Trooper helmet.

Screenshot (5)

Let’s see what are possibilities if we are to fit cat’s face with a Star Corps Clone Trooper Helmet

Screenshot (6)

 

Screenshot (7)

Bad target arises when Tom’s picture is in complex because Jerry is there and it is of low resolution

Screenshot (8)

Fluff friend cat called Syri and Garfield looks so common. The colour are the same and they have no special features, and they are promiscuous. If we have enough amount of pictures and they are in the same pose without distortion, it help with the design.

Screenshot (9)

To discriminate them for helmet design, we need to understand their special features. If they are too similar, we may misidentify closely related cats such as the two kitties from Sanrio. It shows the reason why something we are targeting can fit the same models (this may cause drug’s side effects in the case of kinases)

Screenshot (10)

Felix and Sylvester are unique. They are easy for the design of specific helmets for masking them.Screenshot (11)Most of the effort is CRISPR-cas9 is devoted to find a smart synthetic cat or a helmet that can perform our goal to control these mask singers.

 

 

 

Purpose of Life

At night on recliner chair,
Somewhere in quiet corner,
I was thinking and wonder
What is the purpose of life?
It is neither a trip to see God,
Nor a praise on award and prize.
It is the peace of mind
When life is on struggle.
Destination is just one end.
Life happened to be a hassle
Along roads and river of the world,
I puddle and sometimes have to climb
Up to the top of the mount,
Heading south and north and up the sky.
Well rounded experience till we die
Should be used to try to answer:
The great mystery of the earth,
The birth of a new discipline,
The revolutionized way of doctrine,
To imagine quarks to the universe,
To link the molecules to diseases,
To release energy of mother earth,
To cure the incurables and to reverse,
The curse from sickness to healthy lives.
-Wi Tanramluk

Newton and I

เมื่อฉันรู้ว่าเป็นศิษย์ของปรมาจารย์ปู่ Sir Isaac Newton

When I know that my academic genealogy can be traced back to Sir Isaac Newton.

 

C6fHpoMU0AAoUoB

 

 

17thGenerationsToNewton

Photo Filter

New floral filter on App Looks
It took pictures so pretty
That’s only in my fantasies,
The real me looks nothing like it’s shown.
Today I feel so exhausted
I paused to play with deceiver
And it lies that I am young forever
What matter was a girl hidden inside
Wrinkles and dark circles around eyes
Freckles got from sunshine every morning
Tears of joy, marks from smile and frowning
Causing this poor thing to get old.
Is it matter how she looks like
If she’s nice and kind as ever.
Some say that it does not matter
So please smile to her when we see.
Baby days so frequent at the peak,
People seek and hide smiling
At forty life got interesting,
But smiling was something a bit rare,
As it seems hidden with what’s inside.
So people don’t smile frequently
Therein hidden unsung story
So pity most are not to be told
To people around from outside
And all kinds of those stranger
Busy life goes by forever
The closer circle was so small.
Till one day the muscles were numb
One only feel handsome on selfie
An unpurposeful smile becomes cheesy
Whilst it used to be best medicine.

Mahori Tutorial 2

How to observe drug’s fragment interaction with protein residues to understand drug selectivity. In this example, I show you how to make Mahori query and get a comparison page showing the interaction that one part of the ligand have with different enzymes from the PDB.