Early in the day, sky is dull
Just like our courage when beginning.
With progress through the day, it’s shining
Nicest thing happens when the time is ripe.
Photos taken by Wi on 31/5/2018 at Petchburi, Thailand
Bored at Work
The road is full of flowers.
Nature awarded you with these prize
Walking to see butterflies…
Free my mind from a tight cubicle
Of dim light & room full of papers,
Computer-generated pollutant,
Block my mind, blur my sight, freeze my hand.
Let’s make plan, see flowers, worth the time.
Non-perfectionism
Once I asked my sis what is best
When my hair is straight or updo
My sis say it is all up to you
Woman do have several styles.
Nothing is the best of all things
We can bring our looks to all types
Today, tomorrow, all those kinds
just what you feel like, do them all.
#philosophyofhairdo #non-perfectionism
Analogy of Drug Target in cartoon
My analogy of cat’s face with drug target such as HIV-protease. What makes them look like a cat? Conserved features (ears and whiskers), and Differential features (eyes and the shape of the face)
Drug is an inhibitor that stop the cat from meowing, such as this Star Corps Trooper helmet.
Let’s see what are possibilities if we are to fit cat’s face with a Star Corps Clone Trooper Helmet
Bad target arises when Tom’s picture is in complex because Jerry is there and it is of low resolution
Fluff friend cat called Syri and Garfield looks so common. The colour are the same and they have no special features, and they are promiscuous. If we have enough amount of pictures and they are in the same pose without distortion, it help with the design.
To discriminate them for helmet design, we need to understand their special features. If they are too similar, we may misidentify closely related cats such as the two kitties from Sanrio. It shows the reason why something we are targeting can fit the same models (this may cause drug’s side effects in the case of kinases)
Felix and Sylvester are unique. They are easy for the design of specific helmets for masking them.
Most of the effort is CRISPR-cas9 is devoted to find a smart synthetic cat or a helmet that can perform our goal to control these mask singers.
Purpose of Life
At night on recliner chair,
Somewhere in quiet corner,
I was thinking and wonder
What is the purpose of life?
It is neither a trip to see God,
Nor a praise on award and prize.
It is the peace of mind
When life is on struggle.
Destination is just one end.
Life happened to be a hassle
Along roads and river of the world,
I puddle and sometimes have to climb
Up to the top of the mount,
Heading south and north and up the sky.
Well rounded experience till we die
Should be used to try to answer:
The great mystery of the earth,
The birth of a new discipline,
The revolutionized way of doctrine,
To imagine quarks to the universe,
To link the molecules to diseases,
To release energy of mother earth,
To cure the incurables and to reverse,
The curse from sickness to healthy lives.
-Wi Tanramluk
Why drug design researchers need MANORAA?
- We are in the era with 100,000 protein structures available. Now we need to analyse what the crystallographic community already have rather than predicting probes in the vacuum.
- When you know the ligand is bound inside the identifiable PDB crystal structure, it is surely affect that protein and we showed you the associated Ki from peer-review literature. So that is how we build the bridge from structures to precision medicine.
- The residues that you want to fish out from the multiple alignment conservation may be there but may not be a must. The atoms that must be there are atoms that stay there and pair up with the ligand most of the time. The residues that causes the change in binding affinities is what you want to fish for selectivity.
- What the drug community need is perhaps a linker such as MANORAA to go all the way from ligands to proteins, pathways, SNPs and target human organs plus a bit of help from the collaborative effort from various disciplines.
- It is the very first attempt that ligand structures can complement the drug discovery pipeline with mostly experimental data source support to the expression levels.
- It works on your phone, tablet, mac and PC so I can browse my drug on the go.
- Its ligand superposition function allows you to make programmable code for fragments superposition on the URL so your drug fragment remains anonymous.
- It is open and free but we will need to survive on citation.
Reference: MANORAA paper
Newton and I
เมื่อฉันรู้ว่าเป็นศิษย์ของปรมาจารย์ปู่ Sir Isaac Newton
When I know that my academic genealogy can be traced back to Sir Isaac Newton.
Old Book Chemistry
Digging through old books from the shelf,
Discovered thyself memory.
Old books have some chemistry
From primary school back then.
I dreamt to reach the star
Thus far seems out of my fence.
My imaginary abstinence
Has happened from so many things.
Out of my familiar zone,
On a few smart phones and my bench,
Distraction that I have befriended
Suck persistence out from my soul.
Is this called a burn out–
When we’re aroused by nothingness?
Should not that be a bless
To access window of the life,
When fire inside was absent
When we don’t want to fight
When mountain seems so high
&Simple life is my medal.
Photo Filter
New floral filter on App Looks
It took pictures so pretty
That’s only in my fantasies,
The real me looks nothing like it’s shown.
Today I feel so exhausted
I paused to play with deceiver
And it lies that I am young forever
What matter was a girl hidden inside
Wrinkles and dark circles around eyes
Freckles got from sunshine every morning
Tears of joy, marks from smile and frowning
Causing this poor thing to get old.
Is it matter how she looks like
If she’s nice and kind as ever.
Some say that it does not matter
So please smile to her when we see.
Baby days so frequent at the peak,
People seek and hide smiling
At forty life got interesting,
But smiling was something a bit rare,
As it seems hidden with what’s inside.
So people don’t smile frequently
Therein hidden unsung story
So pity most are not to be told
To people around from outside
And all kinds of those stranger
Busy life goes by forever
The closer circle was so small.
Till one day the muscles were numb
One only feel handsome on selfie
An unpurposeful smile becomes cheesy
Whilst it used to be best medicine.
Life of Cactus
Medium: Gelly roll stardust on Black paper
I want to be like a little cactus,
Growing strong on sand and dust.
Adapting to desert afar
Or living in a tiny jar.
Facing the sun when it is hot
Protect itself with thorn it’s got.
Then comes the time it has flowers
So rare that makes people wonder.
Learning to thrive on limitation
Even when life was like fiction.
-Wi Tanramluk
