Structural Bioinformatics & Drug Design Lecture: Part I

Lesson Plan

Program         Molecular Genetics and Genetic Engineering

Course            MBMG 515 Protein Technologies and Applications

Lecture topic Drug Design

Lecturer         Asst.Prof. Dr.Duangrudee Tanramluk

Date/Time      Friday 2 December 2022 (13.00  ̶  15.00 hrs)

Room              Third Floor Computer Room at MB

Learning Objectives:

            At the end of this lecture, students should be able to                    

  1. Explain basis of computational approaches for drug discovery
  2. Discuss advantages and disadvantages of recent techniques used for drug design
  3. Perform how to use tool and online resources to obtain information about small molecule drug target

Content Outlines:

Overview of drug discovery, drug design techniques, structure-based drug design, ligand-based drug design, recent computer application for drug discovery


Hung, C. L. and C. C. Chen (2014). “Computational approaches for drug discovery.” Drug Dev Res 75(6): 412 ̶ 418.

Learning organization:

  1. Lecture (2 hours)
  2. Hands on (1 hours)

Learning materials provided:

  1. Interactive PowerPoint slides
  2. Hand out
  3. Online Video demo and workshop

Class Materials


1. Go to, click on Sample page under the logo, explain how the amount of hydrogen bonds + ionic interaction and structural conservation might be useful for drug design.

2. Pick one drug and make an all English infographic chart of the drug’s target protein, pathways, human organ, expression levels and, if available, SNPs. Put them together in one poster called YourName_YourDrug.pptx

(You can download example template here! )